MovDisordV3, Main, Exploration, bibRecord, 004C72

Positron emission tomographic studies in restless legs syndrome

Identifieur interne : 004C72 ( Main/Exploration ); précédent : 004C71; suivant : 004C73

Positron emission tomographic studies in restless legs syndrome

Auteurs : Claudia Trenkwalder [Allemagne] ; Arthur S. Walters [États-Unis] ; Wayne A. Hening [États-Unis] ; Sudhansu Chokroverty [États-Unis] ; Angelo Antonini [États-Unis] ; Vijay Dhawan [États-Unis] ; David Eidelberg [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 1999-01.

RBID : ISTEX:40F9C1EEE3E5C17FE336545F551138275DB655AB

Descripteurs français

Pascal (Inist)
- Adulte, Exploration radioisotopique, Fluor 18 FDG, Fluorodopa(18F), Impatience membre inférieur syndrome, Métabolisme, Pathogénie, Positon, Récepteur dopaminergique, Tomoscintigraphie, Utilisation cérébrale locale glucose.
Wicri :
- topic : Adulte.

English descriptors

KwdEn :
- Adult, Aged, Brain (physiopathology), Brain (radionuclide imaging), Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (diagnostic use), Dopamine receptor, Emission tomography, Energy Metabolism (physiology), Female, Fluorodeoxyglucose, Fluorodeoxyglucose F18 (diagnostic use), Fluorodopa, Fluorodopa(18F), Humans, Local cerebral glucose utilization, Male, Metabolism, Middle Aged, Pathogenesis, Periodic limb movements (PLM), Positron, Positron emission tomography (PET), Radionuclide study, Receptors, Dopamine (physiology), Receptors, Presynaptic (physiology), Restless Legs Syndrome (physiopathology), Restless Legs Syndrome (radionuclide imaging), Restless legs syndrome, Restless legs syndrome (RLS), Sleep disorders, Tomography, Emission-Computed.
MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , diagnostic use : Dihydroxyphenylalanine, Fluorodeoxyglucose F18.
- physiology : Energy Metabolism, Receptors, Dopamine, Receptors, Presynaptic.
- physiopathology : Brain, Restless Legs Syndrome.
- radionuclide imaging : Brain, Restless Legs Syndrome.
- Aged, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed.

Abstract

We studied six restless legs syndrome (RLS) patients with [F18]fluorodeoxyglucose (FDG) positron emission tomography (PET). We also studied four of these same patients with [F18]fluorodopa (FDOPA) PET. The patients' FDG and FDOPA PET scans were compared with those from age‐matched healthy control subjects. No significant differences between the two groups were found for any regional blood flow values derived from the FDG scans or for any binding constants derived from the FDOPA scans. These results suggest that any abnormal resting brain metabolic activity or putative presynaptic dopaminergic defect in RLS is likely either to be so subtle that it is below the threshold for ready detection by PET or that it is located in an area of neural tissue inaccessible to the current scanner. No substantial defect is likely to involve the dopaminergic nigrostriatal axis.

Url:

https://api.istex.fr/document/40F9C1EEE3E5C17FE336545F551138275DB655AB/fulltext/pdf

DOI: 10.1002/1531-8257(199901)14:1<141::AID-MDS1024>3.0.CO;2-B

Affiliations:

Le document en format XML

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<author><name sortKey="Chokroverty, Sudhansu" sort="Chokroverty, Sudhansu" uniqKey="Chokroverty S" first="Sudhansu" last="Chokroverty">Sudhansu Chokroverty</name>
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<author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name>
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<term>Aged</term>
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<term>Brain (radionuclide imaging)</term>
<term>Dihydroxyphenylalanine (analogs & derivatives)</term>
<term>Dihydroxyphenylalanine (diagnostic use)</term>
<term>Dopamine receptor</term>
<term>Emission tomography</term>
<term>Energy Metabolism (physiology)</term>
<term>Female</term>
<term>Fluorodeoxyglucose</term>
<term>Fluorodeoxyglucose F18 (diagnostic use)</term>
<term>Fluorodopa</term>
<term>Fluorodopa(18F)</term>
<term>Humans</term>
<term>Local cerebral glucose utilization</term>
<term>Male</term>
<term>Metabolism</term>
<term>Middle Aged</term>
<term>Pathogenesis</term>
<term>Periodic limb movements (PLM)</term>
<term>Positron</term>
<term>Positron emission tomography (PET)</term>
<term>Radionuclide study</term>
<term>Receptors, Dopamine (physiology)</term>
<term>Receptors, Presynaptic (physiology)</term>
<term>Restless Legs Syndrome (physiopathology)</term>
<term>Restless Legs Syndrome (radionuclide imaging)</term>
<term>Restless legs syndrome</term>
<term>Restless legs syndrome (RLS)</term>
<term>Sleep disorders</term>
<term>Tomography, Emission-Computed</term>
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<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Dihydroxyphenylalanine</term>
<term>Fluorodeoxyglucose F18</term>
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<term>Receptors, Dopamine</term>
<term>Receptors, Presynaptic</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term>
<term>Restless Legs Syndrome</term>
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<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term>
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<term>Métabolisme</term>
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<term>Positon</term>
<term>Récepteur dopaminergique</term>
<term>Tomoscintigraphie</term>
<term>Utilisation cérébrale locale glucose</term>
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<front><div type="abstract" xml:lang="en">We studied six restless legs syndrome (RLS) patients with [F18]fluorodeoxyglucose (FDG) positron emission tomography (PET). We also studied four of these same patients with [F18]fluorodopa (FDOPA) PET. The patients' FDG and FDOPA PET scans were compared with those from age‐matched healthy control subjects. No significant differences between the two groups were found for any regional blood flow values derived from the FDG scans or for any binding constants derived from the FDOPA scans. These results suggest that any abnormal resting brain metabolic activity or putative presynaptic dopaminergic defect in RLS is likely either to be so subtle that it is below the threshold for ready detection by PET or that it is located in an area of neural tissue inaccessible to the current scanner. No substantial defect is likely to involve the dopaminergic nigrostriatal axis.</div>
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Movement Disorders (revue)

Positron emission tomographic studies in restless legs syndrome

Positron emission tomographic studies in restless legs syndrome

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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